abstract：:The relationship between dimethylnitrosamine (DMN) demethylase activity and DMN-induced mutagenesis was investigated in Drosophila melanogaster. The activity of DMN-demethylase was at least 10-fold greater in the Hikone-R strain than in three other Drosophila strains. However, the sex-linked recessive lethal (SLRL) mu...

journal_title：Chemico-biological interactions

authors： Waters LC,Nix CE,Epler JL

更新日期：1983-08-15 00:00:00

abstract：:The metabolic activation of benzo[a]pyrene (BP) was examined in six samples of human skin after topical application of the hydrocarbon to the skin in short-term organ culture. The results show that all of the samples were capable of metabolizing BP to water-soluble products and to ether-soluble products that included ...

journal_title：Chemico-biological interactions

authors： Weston A,Grover PL,Sims P

更新日期：1983-08-01 00:00:00

abstract：:Ultraviolet absorption data and thermal chromatography through hydroxyapatite (HAP) column revealed that furazolidone treatment of Vibrio cholerae cells produced more than 80% of DNA reversibly bihelical due to the formation of interstrand cross-links and the reaction obeyed a first order relation. Sensitivities of th...

journal_title：Chemico-biological interactions

authors： Chatterjee SN,Banerjee SK,Pal AK,Basak J

更新日期：1983-08-01 00:00:00

abstract：:Exposure of mice to 14C-labelled ethene or ethene oxide gave rise to hydroxyethylations of nucleophilic sites in hemoglobin and DNA. The relative amounts of alkylation products of different amino acids in hemoglobin were the same for the two compounds. Furthermore, the ratio between the degree of alkylation of DNA in ...

journal_title：Chemico-biological interactions

authors： Segerbäck D

更新日期：1983-07-15 00:00:00

abstract：:Oral administration of O,O,S-trimethyl phosphorothioate (OOS), an impurity present in widely used organophosphorus insecticides, causes delayed toxicity in rats, i.e., death occurring as late as 28 days after the treatment. The signs of toxicity include body weight loss (maximum on day 3), red staining around the nose...

journal_title：Chemico-biological interactions

authors： Imamura T,Hasegawa L,Gandy J,Fukuto TR

更新日期：1983-07-01 00:00:00

abstract：:Colloidal silical particles were produced at a size that permitted reaction with human erythrocytes and rat macrophages without affecting cell integrity. Binding of colloid was shown by increased electrophoretic mobility of red cells and also resulted in changes in the surface topography of red cells as seen with scan...

journal_title：Chemico-biological interactions

authors： Cantrell AC,Ellis P

更新日期：1983-04-01 00:00:00

abstract：:Mode of interaction of mercuric mercury and selenite in rabbit blood was investigated in vitro. After the incubation of rabbit blood with 10(-5) M each of 203HgCl2 and Na2(75)SeO3, the amounts of both 203Hg and 75Se incorporated into erythrocytes were markedly larger than the case where the blood was treated separatel...

journal_title：Chemico-biological interactions

authors： Naganuma A,Imura N

更新日期：1983-03-01 00:00:00

abstract：:Perinatal development of rat liver nuclear membrane enzymatic activities was investigated with respect to the metabolism of xenobiotica. The qualitative pattern observed was very close to that reported for microsomal enzymes during development. Cytochrome P-450, NADPH-cytochrome c reductase and ethoxycoumarin deethyla...

journal_title：Chemico-biological interactions

authors： Romano M,Clos V,Assael BM,Salmona M

更新日期：1982-11-01 00:00:00

abstract：:Caffeine was found to potentiate the cytotoxic effect of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro. This enhancement of toxicity is shown to occur under both aerobic and hypoxic conditions. Split dose experiments indicate that the general shape of the hypoxic surviva...

journal_title：Chemico-biological interactions

authors： Horsman MR,Stratford IJ

更新日期：1982-08-01 00:00:00

abstract：:In the series of tetraalkylammonium ions from tetramethylammonium to tetra-n-heptylammonium, tetra-n-pentylammonium ion was a potent protector of both murine L1210 leukemia and bone marrow progenitor cells against mechlorethamine cytotoxicity. It was also a non-competitive inhibitor of choline uptake. Phosphonium anal...

journal_title：Chemico-biological interactions

authors： Naujokaitis SA,Fisher JM,Rabinovitz M

更新日期：1982-06-01 00:00:00

abstract：:In CF1 mice lindane treatment led to a significant increase in liver tumor incidence whilst in Osborne-Mendel rats it was not carcinogenic. Although somewhat less clear, the test in B6C3F1 mice led to the conclusion that under the conditions of the bioassay lindane was not carcinogenic for this strain. In this study, ...

journal_title：Chemico-biological interactions

authors： Oesch F,Friedberg T,Herbst M,Paul W,Wilhelm N,Bentley P

更新日期：1982-05-01 00:00:00

abstract：:It has been postulated that reversible, high-affinity binding of 3-methylcholanthrene(MC)-type inducers to a receptor protein (the Ah receptor) in hepatic cytosol is essential for induction of aryl hydrocarbon hydroxylase (AHH) enzymic activity. To test this postulate, the binding affinities of 16 highly-purified, syn...

journal_title：Chemico-biological interactions

authors： Bandiera S,Safe S,Okey AB

更新日期：1982-04-01 00:00:00

abstract：:The following organophosphates were tested for their ability to induce DNA damage in a rec-type repair test with Proteus mirabilis strains PG713 (rec- hcr-) and PG273 (wild type) and point mutations in his- strain TA100 of Salmonella typhimurium--butonate: O,O-dimethyl-(1-n-butyryloxy-2,2,2-trichloroethyl)-phosphonate...

journal_title：Chemico-biological interactions

authors： Braun R,Schöneich J,Weissflog L,Dedek W

更新日期：1982-04-01 00:00:00

abstract：:A model is presented which correlates the survival of normal human fibroblasts (NF) after exposure to N-acetoxy-2-acetylaminofluorene (N-AcO-AAF) with the rate of excision of carcinogen residues bound to DNA. Measurements of the rate of excision of carcinogen residues suggest that this is a first-order process with 37...

journal_title：Chemico-biological interactions

authors： Miller JH,Heflich RH

更新日期：1982-03-01 00:00:00

abstract：:Numerous xenobiotics are known to be bioactivated and to covalently and to proteins, but the resulting amino acid adducts (AAAs) are unknown. In this study the AAAs of twelve 14C-labeled aliphatic halides were examined after formation in an in vitro microsomal system. After exhaustive solvent extraction of the precipi...

journal_title：Chemico-biological interactions

authors： Maiorino RM,Gandolfi AJ,Brendel K,Mac Donald JR,Sipes IG

更新日期：1982-01-01 00:00:00

abstract：:Sensitivities of the strains belonging to four vibrio biotypes to the action of furazolidone were investigated. Vibrio cholerae (classical) was most and Vibrio parahaemolyticus least sensitive to this drug. Statistical analyses revealed significant differences between any two of the four types of vibrio in respect of ...

journal_title：Chemico-biological interactions

authors： Banerjee SK,Chatterjee SN

更新日期：1981-11-01 00:00:00

abstract：:The effects of norharman (NH) on the metabolism of dibenzo[a,e]-fluoranthene (DBF) and on its fixation on DNA, RNA and proteins have been studied in vitro by incubation with S-9 and microsomes from rats and mice. NH causes a decrease of the activity of microsome monooxygenases proportionally to its concentration but h...

journal_title：Chemico-biological interactions

authors： Perin-Roussel O,Ekert B,Zajdela F

更新日期：1981-10-01 00:00:00

abstract：:Administration of a single oral dose of dieldrin (20 mg/kg body wt.) to rhesus monkeys considerably elevated the uptake of glucose and the activities of brush border sucrase, lactase, maltase and alkaline phosphatase in intestine compared to control animals. Leucine uptake and leucine amino peptidase activity was sign...

journal_title：Chemico-biological interactions

authors： Mahmood A,Agarwal N,Sanyal S,Dudeja PK,Subrahmanyam D

更新日期：1981-10-01 00:00:00

abstract：:DNA-protein cross-links were detected in several types of mammalian cells in culture when they were exposed to chromate salts. The cell types included human bronchial epithelial cells--the apparent cell type of origin of the malignancies reported in chromate workers. The level of cross-linking was proportional to the ...

journal_title：Chemico-biological interactions

authors： Fornace AJ Jr,Seres DS,Lechner JF,Harris CC

更新日期：1981-09-01 00:00:00

abstract：:Misonidazole is readily reduced by zinc dust in aqueous solution in the presence of ammonium chloride. High pressure liquid chromatographic (HPLC) separation of the reduction mixture revealed the presence of three products. These were identified as the hydroxylamine, amine and the hydrazo derivative of misonidazole. T...

journal_title：Chemico-biological interactions

authors： Varghese AJ,Whitmore GF

更新日期：1981-08-01 00:00:00

abstract：:Human foreskin cell cultures in scheduled DNA synthesis (S phase) of the cell cycle were exposed to UV irradiation at a dose of 10 J . m-1 in the presence of insulin. These treated cell populations, when selectively passaged in a high amino acid supplemented complete growth medium (CM) after 20 Dulbecco's phosphate bu...

journal_title：Chemico-biological interactions

authors： Milo GE,Weisbrode SA,Zimmerman R,McCloskey JA

更新日期：1981-07-01 00:00:00

abstract：:The 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethene (DDT) metabolic intermediate 1-chloro-2,2-bis(p-chlorophenyl)ethene (DDMU) is partially metabolized in vivo by mice to 2-hydroxy-2,2-bis(p-chlorophenyl)acetic acid (alpha OH-DDA) and other metabolites which are excreted in urine. The subsequent DDT metabolic intermedia...

journal_title：Chemico-biological interactions

authors： Gold B,Leuschen T,Brunk G,Gingell R

更新日期：1981-05-01 00:00:00

abstract：:Levels of mixed-function oxidase (MFO) enzymes were measured in adriamycin(ADR)-sensitive murine leukemia P-388 and its ADR-resistant subline P-388/ADR. The subcellular fractions of the resistant cells showed decreased contents of MFO components, cytochrome P-450 and cytochrome b5, in comparison with the identically p...

journal_title：Chemico-biological interactions

authors： Mungikar A,Chitnis M,Gothoskar B

更新日期：1981-04-01 00:00:00

abstract：:Caffeine was found not to bind covalently to liver microsomal proteins from mice, rats and rabbits. Microsomes metabolized caffeine only to a limited extent, the highest rate (about 2% of the substrate concentration) being obtained with rabbit microsomal preparations. The rat liver perfusion technique represents a goo...

journal_title：Chemico-biological interactions

authors： Szczawinska K,Ginelli E,Bartosek I,Gambazza C,Pantarotto C

更新日期：1981-03-15 00:00:00

abstract：:Reactivity of beta-propiolactone, beta-butyrolactone and gamma-butyrolactone with guanosine, RNA, DNA and 4-(p-nitrobenzyl)pyridine was studied. beta-Propiolactone was 50--100 times more reactive with all the nucleophiles than beta-butyrolactone whereas gamma-butyrolactone was completely inactive. The rate of alkylati...

journal_title：Chemico-biological interactions

authors： Hemminki K

更新日期：1981-03-15 00:00:00

abstract：:The alkylation of hemoglobin is a proposed dose monitor for chemical carcinogens and mutagens. The binding of fifteen chemical carcinogens and mutagens to rat hemoglobin was determined. Direct acting carcinogens and indirect acting carcinogens including aromatic amines, halogenated hydrocarbons, nitrosamines, polycycl...

journal_title：Chemico-biological interactions

authors： Pereira MA,Chang LW

更新日期：1981-01-01 00:00:00

abstract：:Two homogenous fractions of hepatic metallothioneins ((Cd,Zn) MT-1 and (Cd,Zn) MT-2) and renal metal binding proteins ((Bi,Cu) BP-1 and (Bi,Cu) BP-2) were isolated from rats exposed to heavy metals and specific antisera to them were produced in rabbits. These antisera were tested by immunodiffusion and immunoelectroph...

journal_title：Chemico-biological interactions

authors： Zelazowski AJ,Szymańska JA,Cierniewski CS

更新日期：1980-12-01 00:00:00

abstract：:Trypan blue at 50 microgram/ml stimulates the pinocytic uptake of 125I-labelled PVP, but not of colloidal 198Au or formaldehyde-denatured 125I-labelled bovine serum albumin, by the 17.5-day rat visceral yolk sac incubated in vitro. Neither Trypan blue nor a combination of the dye with 125I-labelled PVP stimulated the ...

journal_title：Chemico-biological interactions

authors： Roberts G,Williams KE,Lloyd JB

更新日期：1980-11-01 00:00:00

abstract：:The non-covalent interactions of benzo[a]pyrene (BP) and several of its hydroxylated metabolites with ligandin, aminoazodye-binding protein A (Z-protein, fatty acid binding protein) and lecithin bilayers have been studied by equilibrium dialysis, an adsorption technique and fluorescence spectroscopy. Binding affinitie...

journal_title：Chemico-biological interactions

authors： Tipping E,Moore BP,Jones CA,Cohen GM,Ketterer B,Bridges JW

更新日期：1980-11-01 00:00:00

abstract：:The antitumor activity of a series of diorganotin dihalide and di-pseudohalide complexes, R2SnX2, L2, where R = Methyl (Me), Ethyl (Et), n-Propyl (Pr), n-Butyl (Bu) or Phenyl (Ph); X = F, Cl, Br, I or NCS; and L = O- or N- donor organic ligand, which were modelled on the active platinum complexes, has been investigate...

journal_title：Chemico-biological interactions

authors： Crowe AJ,Smith PJ,Atassi G

更新日期：1980-10-01 00:00:00

abstract：:The influence of systemic application of chemically unrelated drugs and xenobiotics (phenobarbital (PB), rifampicin (Rifa), pregnenolone-16 alpha-carbonitrile (PCN) and 3-methylcholanthrene (MC) on drug metabolizing enzymes was investigated in the skin of rats of both sexes. The results were compared with those obtain...

journal_title：Chemico-biological interactions

authors： Vizethum W,Ruzicka T,Goerz G

更新日期：1980-08-01 00:00:00

abstract：:ATP mediates covalent binding of hydroxymethyl derivatives of aromatic hydrocarbons to DNA. This non-enzymatic reaction has been studied with 6-[14C]hydroxymethylbenzo[alpha]pyrene (]14C]BP-6-CH2OH) and 7-[14C]-hydroxymethylbenz[alpha]anthracene ([14C]BA-7-CH2OH) at 37 degrees C in Tris buffer (pH 7.0). While ADP medi...

journal_title：Chemico-biological interactions

authors： Rogan EG,Roth RW,Katomski-Beck PA,Laubscher JR,Cavalieri EL

更新日期：1980-07-01 00:00:00

abstract：:We investigated the permeabilities of lipid bilayers to the neurotoxin methylmercuric chloride (MMC). This mercurial is an efficient collisional quencher of the fluorescence of N-alkyl carbazole derivatives. Quenching of the fluorescence of beta-(3-(9-carbazole)-propionyl-L-alpha-phosphatidylcholine (CPA-PC) in vesicl...

journal_title：Chemico-biological interactions

authors： Lakowicz JR,Anderson CJ

更新日期：1980-06-01 00:00:00

abstract：:The dietary exposure of rats to cadmium (75 ppm) for periods of up to 48 weeks caused an accumulation of cadmium in the femur, and an inhibition of the accumulation of zinc in the bone. After 48 weeks of cadmium treatment, there was a decreased activity of alkaline phosphatase in the femur. This effect was prevented b...

journal_title：Chemico-biological interactions

authors： Bonner FW,King LJ,Parke DV

更新日期：1980-03-01 00:00:00

abstract：:Excision repair was measured in normal human and xeroderma pigmentosum group C fibroblasts treated with ultraviolet radiation and the carcinogens acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide (4NQO) by the techniques of unscheduled synthesis, photolysis of bromodeoxyuridine incorporated into parental DNA duri...

journal_title：Chemico-biological interactions

authors： Ahmed FE,Setlow RB

更新日期：1980-01-01 00:00:00

abstract：:The unwinding of superhelical Col E1-DNA was studied by means of gel electrophoresis and electron microscopy after covalent binding of N-acetoxy-N-2-[14C]acetylaminofluorene (N-Aco-[14C]AAF) and its 7-iodo derivative (N-Aco-[14C]AAIF). Studies with both compounds indicated that complete unwinding of the supercoiled DN...

journal_title：Chemico-biological interactions

authors： Lang MC,Freund AM,de Murcia G,Fuchs RP,Daune MP

更新日期：1979-12-01 00:00:00

abstract：:The efficiency of multiplicity reactivation of T4 particles inactivated by platinum(II) complexes is very low. The same is true for marker rescue and functional survival of genes. This can be at least partly explained by the inability of most inactivated virus particles to introduce their DNA into the host cells as de...

journal_title：Chemico-biological interactions

authors： Kerszman G,Josephsen J,Fernholm B

更新日期：1979-12-01 00:00:00

abstract：:The effect of repeated parenteral administration of cadmium (0.75, 1.5 and 3.0 mg/kg) on tissue disposition and urinary excretion of cadmium, zinc, copper and iron has been studied in the male rat. Cadmium, zinc and copper accumulated in liver and kidney, but the concentration of iron did not alter significantly. The ...

journal_title：Chemico-biological interactions

authors： Bonner FW,King LJ,Parke DV

更新日期：1979-10-01 00:00:00

abstract：:In comparison with the fluorescence emission spectra of 7-methylbenz[a]-anthracene-nucleoside adducts, the fluorescence emission spectra of hydrocarbon-deoxyribonucleoside adducts containing a methyl substituent in the "bay region" lack spectral resolution at room temperature and appear at substantially longer wavelen...

journal_title：Chemico-biological interactions

authors： Moschel RC,Hudgins WR,Dipple A

更新日期：1979-09-01 00:00:00

abstract：:DNA damage and DNA repair have been observed in cultured human skin fibroblasts exposed to potassium chromate but not to a chromic glycine complex. DNA repair synthesis (unscheduled incorporation of [3H]thymidine (TdR)) was measured in cells during or following exposure to chromate and was significant for chromate con...

journal_title：Chemico-biological interactions

authors： Whiting RF,Stich HF,Koropatnick DJ

更新日期：1979-08-01 00:00:00